Trajectories of pain over 6 years in early Parkinson’s disease: ICICLE-PD
This longitudinal study tracks pain trajectories over six years in early Parkinson’s disease, identifying distinct pain phenotypes and demonstrating increasing prevalence with disease progression.
Post-stroke pain
This expert review examines post-stroke pain syndromes, including central post-stroke pain, musculoskeletal pain, and spasticity-related pain, addressing mechanisms and evidence-based treatments.
Chronic Pain After Traumatic Brain Injury: Pathophysiology and Pain Mechanisms
This review examines chronic pain pathophysiology after traumatic brain injury, exploring neuroinflammation, altered pain processing, and shared mechanisms with headache and neuropathic pain.
Virtual reality for cancer symptom management: a systematic review of randomized controlled trials
Systematic review of 15 RCTs shows VR effectiveness in reducing physical symptoms like pain and fatigue, and psychological symptoms including anxiety and depression in cancer patients.
Effectiveness of Virtual Reality in Anxiety and Pain Management in Children and Adolescents Receiving Cancer Treatment
Meta-analysis of 14 RCTs shows VR has a medium, significant effect on reducing pain and anxiety in children receiving cancer treatment, with age moderating effectiveness.
Immersive and Non-Immersive Virtual Reality for Pain and Anxiety Management in Pediatric Patients with Hematological or Solid Cancer
Systematic review of 13 studies shows VR beneficial effects during painful vascular access procedures in pediatric cancer patients, with limited evidence for anxiety reduction.
A synthesis of meta-analyses of immersive virtual reality interventions in pain
Umbrella review of 54 meta-analyses demonstrates immersive VR is efficacious for procedural pain. Evidence for chronic pain shows only short-term pain intensity improvements.
Extended reality used in the treatment of phantom limb pain: a multicenter, double-blind, randomized controlled trial
Multicenter double-blind RCT comparing phantom motor execution versus imagery using extended reality. Both interventions reduced pain by approximately 65-68%.
Characteristics of Phantom Limb Pain Alleviated with Virtual Reality Rehabilitation
In 19 amputees, VR rehabilitation reduced phantom limb pain and improved movement representation. Relief was associated with kinesthesia-related symptoms, not somatosensory pain.
Clinical Trial of the Virtual Integration Environment to Treat Phantom Limb Pain With Upper Extremity Amputation
Fourteen service members with upper limb amputation used a VR simulator. After ~18 sessions, 88% reduced phantom limb pain and 80% reduced residual limb pain.